1. Introduction 1.1 The Five-Year Milestone In November 2025, the scientific community arrived at a pivotal vantage point: the fifth anniversary of the unveiling of AlphaFold 2. As reported by Ewen Callaway in Nature , this milestone offers a unique opportunity to survey a revolution that has fundamentally altered the landscape of structural biology, pharmacology, and evolutionary science. 1  What began as an entry in a computational competition has metastasized into the oper

Abstract The meteoric rise of the Transformer architecture has defined the last decade of artificial intelligence, yielding Large Language Models (LLMs) of unprecedented capability. Yet, despite their fluency, these models remain fundamentally static entities—statistical correlators frozen in time, bounded by finite context windows and divorced from the biological mechanisms of the brains they seek to emulate. This report provides an exhaustive analysis of the "Dragon Hatchli